Effects of Polybrominated Biphenyls (PBB) on Immune Response in Rodents
نویسندگان
چکیده
منابع مشابه
Effects of polybrominated biphenyls (PBB) on immune response in rodents.
Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure severely depressed cell mediated immunity in both mice and rats at the higher...
متن کاملEmbryotoxic effects of polybrominated biphenyls (PBB) in rats.
Pregnant Sprague Dawley rats were given 0, 0.25, 0.5, 1, 5, and 10 mg of a commercial polybrominated biphenyl, FireMaster BP-6 (PBB), in olive oil by gavage each day from days 7 through 15 of pregnancy. Laboratory chow and water were given ad libitum. Treatment with PBB had no significant effect on body weight gain, food and water consumption, and urine production. The mothers were killed on da...
متن کاملPersistence of polybrominated biphenyls (PBB) in human post-mortem tissue.
Polybrominated biphenyl (PBB), a fire retardant, was accidentally substituted for an animal feed supplement in Michigan 10 years ago. This led to widespread livestock contamination and ultimately to contamination of virtually every human residing in the State at that time. In order to evaluate the extent of PBB persistence and distribution in human tissues 10 years after this accidental poisoni...
متن کاملCutaneous effects of exposure to polybrominated biphenyls (PBBs): the Michigan PBB incident.
In 1973 an environmental accident occurred in northern Michigan in which 1000-2000 pounds of the toxic fire retardant polybrominated biphenyl (PBB) was added to the livestock food supply of much of northern Michigan. PBB is highly lipophilic. poorly metabolized, and biocumulative. It subsequently entered the human food chain of the entire state of Michigan. Health effects were noted in contamin...
متن کاملToxicity of polybrominated biphenyls Firemaster BP-6 in rodents.
Pregnant rodents were fed concentrations of a mixture of polybrominated biphenyls (Firemaster BP-6) during the pregnancy. The material appears to be weakly teratogenic, causing exencephaly and cleft palate in mice. Decreasing birth weight with increasing dosage of the material was seen in both mice and rats. Nonpregnant mice fed 1000 ppm Firemaster BP-6 for 11 days had a marked increase in live...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1978
ISSN: 0091-6765
DOI: 10.2307/3428765